Take US-33 East, Exit 46 B, following US-33 E for approximately 68 miles from I-270 to get to Athens.

Business US-33 goes through the city of Lancaster, encountering numerous traffic lights. The first part of the Lancaster bypass is now open, and we do advise that you use it, staying on US-33 instead of taking the Business Route exit as you approach Lancaster. At this time, the bypass ends at US-22; there is limited signage guiding you back to US-33 East. Turn left onto US-22 East, in order to return to US-33 East in Lancaster. Turn right back onto US-33 East at the traffic light for Memorial Drive (there is a CVS Pharmacy on the near-right corner of that intersection). Continue on US-33 East past Logan and through Nelsonville.

After Nelsonville, as you approach Athens, pass the first OH-682 exit (for "The Plains"). If there is a stop sign at the end of the OH-682 off-ramp, you have taken the exit for The Plains. You can either turn right, go to the fourth traffic light and turn left onto Richland Avenue, or get back on the highway and follow the directions in the next paragraph.

After US-33 E joins US-50 W in Athens, take Exit 17, for OH-682 N. Turn right at the first traffic light, onto Richland Avenue, to cross the Hocking River and enter the Ohio University campus. You will be at coordinates E-6 on the campus map, and the Visitor's Center will be located on your left, in the log cabin.